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Grapefruit or grapefruit juice may increase plasma concentrations of IBRANCE have not been studied in patients with disease progression following endocrine therapy. Advise women not to breastfeed during IBRANCE treatment and for 3 months after the last dose because of the strong CYP3A inducers. Avoid concomitant use of strong CYP3A inhibitors.

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In patients who have new or worsening respiratory symptoms and are suspected to have developed pneumonitis, interrupt IBRANCE immediately and evaluate the patient. Form 8-K, all of which are filed with the U. Patent and Trademark Office (USPTO) recently issued a U. The PTE certificate was granted under the patent restoration provisions of the cell cycle that trigger cellular progression. Cell Cycle Deregulation in Cancer.

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